Minimum Inhibitory Concentration (MIC) Assay for Antifungal Drugs
Authors: Jinglin L. Xie,
Sheena D. Singh-Babak and
Leah E. Cowen,
Published: 10/20/2012,
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The Minimum Inhibitory Concentration (MIC) Assay is widely used to measure the susceptibility of yeasts to antifungal agents. In serial two-fold dilutions, the lowest concentration of antifungal drug that is sufficient to inhibit fungal growth is the MIC. Typically, 50% inhibitory (MIC50) or 80% inhibitory (MIC80) values are reported. To facilitate visualization of antifungal susceptibility data, heat maps are generated whereby optical density values are represented quantitatively with colour.