Education
PhD, Institute of Biophysics, Chinese Academy of Science, 2009
Lab information
Protein Preparation and Characterization Facility
http://phoenix.tsinghua.edu.cn/index.php?c=show&id=85
Research focus
Protein expression, purification and characterization
Publications
1. Yuefeng Jiang, Tingting Liu, Chia-Hsueh Lee, Qing Chang, Jing Yang, Zhe Zhang. The NAD+-mediated self-inhibition mechanism of pro-neurodegenerative Sarm1. Nature 588, 658–663 (2020).
2. Yahui Guo, Qing Chang, Liqing Cheng, Sihan Xiong, Xinmin Jia, Xueqiang Zhao, Xin Lin. C-type lectin receptor CD23 is required for host defense against Candida albicans and Aspergillus fumigatus infection. The Journal of Immunology 201(8):2427-2440 (2018).
3. Hai Hou, Yahui Guo, Qing Chang, Tianming Luo, Xin Wu, Xueqiang Zhao. C-type lectin receptor: old friend and new player. Medicinal Chemistry 13(6):536-543 (2017).
4. Xueqiang Zhao, Yahui Guo, Changying Jiang, Qing Chang, Shilei Zhang, Tianming Luo, Bin Zhang, Xinming Jia, Mien-Chie Hung, Chen Dong, Xin Lin. JNK1 negatively controls anti-fungal innate immunity by suppressing CD23 expression. Nature Medicine 23(3):337-346 (2017).
5. Xue-Qiang Zhao, Le-Le Zhu, Qing Chang, Changying Jiang, Yun You, Tianming Luo, Xin-Ming Jia, and Xin Lin. C-type Lectin Receptor Dectin-3 Mediates Trehalose 6,6'-dimycolate (TDM)-induced Mincle expression through CARD9/Bcl10/MALT1 -dependent NF-ĸB Activation. The Journal of Biological Chemistry 289(43):30052-62 (2014).
6. Qing Chang, Xiao-Xue Yan, Shen-Yan Gu, Jun-Feng Liu & Dong-Cai Liang. Crystal structure of human phosphomevalonate kinase at 1.8 Å resolution. PROTEINS-Structure Function and Bioinformatics 73: p254-258 (2008).