Education

PhD, University of Alberta, 2013

Lab information

The Mast lab investigates the dynamic structure and function of peroxisomes in human cells, with a particular focus on their biogenesis, turnover, and roles in innate immunity and cellular stress responses. We integrate advanced live-cell imaging, multiplexed proteomics, and GPU-accelerated 3D image segmentation to study organelle behavior at single-cell resolution. By leveraging systems-level analyses and machine learning approaches, we aim to decode how peroxisomal dysfunction contributes to rare genetic disorders and viral pathogenesis, and to develop novel strategies for organelle-targeted therapeutics.

Research focus

Organelle biology, peroxisomes, infectious diseases, host-pathogen interactions, neurodevelopmental disorders, lipid metabolism, rare diseases, image-based phenotyping, organelle-targeted therapy, viral-host interactions, kinase signaling networks, polyphosphate, precision medicine, de novo organelle biogenesis, single-cell dynamics.

Publications

https://www.ncbi.nlm.nih.gov/myncbi/1lCjeujx8ozAh/bibliography/public/