TY  - JOUR
TI  - Electrophysiological Evaluation of a Sciatic Nerve Degree III Injury Model in Rats
AU  - Chen, Linyu 
AU  - Wang, Ziyi 
AU  - Wang, Chengyao 
AU  - Ma, Ning 
AU  - Zhao, Weiqin 
AU  - Liu, Shuang 
AU  - Lu, Jiajun 
AU  - Zhao, Boyuan 
AU  - Sun, Hong 
AU  - Che, Pengcheng 
AU  - Dou, Na 
VL  - 15
IS  - 10
PY  - 2025
DA  - 2025/05/20
SP  - e5311
C1  - Bio-protocol 2025;15:e5311
DO  - 10.21769/BioProtoc.5311
UR  - https://doi.org/10.21769/BioProtoc.5311
AB  - Sciatic nerve injury is a prevalent traumatic condition that significantly impacts a patient's quality of life. The sciatic nerve compression injury model is among the most commonly utilized models for investigating nerve repair and regeneration. Within this context, the degree III sciatic nerve injury model is frequently employed in scientific research due to its clinical relevance and its suitability for studies focused on functional recovery. However, a standardized approach for accurately assessing the success of constructing the degree III sciatic nerve injury model remains lacking. Traditional macroscopic observation methods exhibit limitations, whereas neurophysiological testing serves as a highly sensitive and objective evaluation technique that can directly reflect changes in nerve conduction function, thus providing reliable quantitative evidence for the successful establishment of the model. This study aims to offer a comprehensive description of the application of neurophysiological techniques in evaluating the construction of the degree III sciatic nerve injury model, thereby ensuring the success of model preparation.
KW  - Sciatic nerve
KW  - Degree III injury
KW  - Model construction
KW  - Neurophysiology
KW  - Conduction velocity
JF  - Bio-protocol
SN  - 2331-8325
PB  - Bio-protocol LLC.
BIO101  - False