TY  - JOUR
TI  - Preparation and Characterization of Poly(2-oxazoline) Micelles for the Solubilization and Delivery of Water Insoluble Drugs
AU  - Vinod, Natasha 
AU  - Hwang, Duhyeong 
AU  - Azam, Salma H. 
AU  - Van Swearingen, Amanda  E. D.
AU  - Wayne, Elizabeth 
AU  - Fussell, Sloane Christian
AU  - Sokolsky-Papkov, Marina 
AU  - Pecot, Chad V.
AU  - Kabanov, Alexander V.
VL  - 11
IS  - 6
PY  - 2021
DA  - 2021/03/20
SP  - e3959
C1  - Bio-protocol 2021;11:e3959
DO  - 10.21769/BioProtoc.3959
UR  - https://doi.org/10.21769/BioProtoc.3959
AB  - Many new drug development candidates are highly lipophilic compounds with low water solubility. This constitutes a formidable challenge for the use of such compounds for cancer therapy, where high doses and intravenous injections are needed (Di et al., 2012). Here, we present a poly(2-oxazoline) polymer (POx)-based nanoformulation strategy to solubilize and deliver hydrophobic drugs. POx micelles are prepared by a simple thin-film hydration method. In this method, the drug and polymer are dissolved in a common solvent and allowed to mix, following which the solvent is evaporated using mild heating conditions to form a thin film. The micelles form spontaneously upon hydration with saline. POx nanoformulation of hydrophobic drugs is unique in that it has a high drug loading capacity, which is superior to micelles of conventional surfactants. Moreover, multiple active pharmaceutical ingredients (APIs) can be included within the same POx micelle, thereby enabling the codelivery of binary as well as ternary drug combinations (Han et al., 2012; He et al., 2016).
KW  - Lipophilic
KW  - Poly(2-oxazoline)
KW  - Nanoformulation
KW  - Surfactants
KW  - Active pharmaceutical ingredients
KW  - Polymeric micelles
JF  - Bio-protocol
SN  - 2331-8325
PB  - Bio-protocol LLC.
BIO101  - False