TY  - JOUR
TI  - Partial Transection of Adult Rat Optic Nerve as a Model of Secondary Degeneration in the Central Nervous System
AU  - Bartlett, Carole A
AU  - Fitzgerald, Melinda 
VL  - 8
IS  - 24
PY  - 2018
DA  - 2018/12/20
SP  - e3118
C1  - Bio-protocol 2018;8:e3118
DO  - 10.21769/BioProtoc.3118
UR  - https://doi.org/10.21769/BioProtoc.3118
AB  - Injury to the central nervous system is characterized by damage that spreads from the initial point of impact into the surrounding adjacent tissue, in a phenomenon referred to as secondary degeneration. The optic nerve can be used to effectively model injury and secondary degeneration to white matter tracts. Partial transection of the dorsal aspect of the nerve leaves the ventral aspect initially undamaged but vulnerable to secondary degeneration, allowing study of tissue exclusively vulnerable to secondary degeneration. Thus the partial optic nerve transection model of secondary degeneration is a valuable tool to study the pathology of spreading damage following neurotrauma and can be used to assess potential efficacy of therapeutic strategies.
KW  - Neurotrauma
KW  - Secondary degeneration
KW  - Partial optic nerve transection
KW  - Visual system
KW  - Optic nerve
JF  - Bio-protocol
SN  - 2331-8325
PB  - Bio-protocol LLC.
BIO101  - False