TY  - JOUR
TI  - A Rodent Model for Chronic Brain Hypoperfusion Related Diseases: Permanent Bilateral Occlusion of the Common Carotid Arteries (2VO) in Rats
AU  - Yan, Mei-Ling 
AU  - Ai, Jing 
VL  - 8
IS  - 1
PY  - 2018
DA  - 2018/01/05
SP  - e2668
C1  - Bio-protocol 2018;8:e2668
DO  - 10.21769/BioProtoc.2668
UR  - https://doi.org/10.21769/BioProtoc.2668
AB  - Permanent occlusion of bilateral common carotid arteries (2VO) in rat is considered as a suitable animal model to mimic chronic brain hypoperfusion status, which is proved to be a risk factor to precede the Alzheimer’s disease or/and vascular dementia. In this protocol, we describe how to successfully ligate the bilateral common carotid arteries covered by anterior cervical muscle group, and provide the details for understanding the surgical procedures of 2VO.
KW  - Permanent occlusion of bilateral common carotid arteries
KW  - Chronic brain hypoperfusion
KW  - Rat
JF  - Bio-protocol
SN  - 2331-8325
PB  - Bio-protocol LLC.
BIO101  - False