TY  - JOUR
TI  - Intracaecal Orthotopic Colorectal Cancer Xenograft Mouse Model
AU  - Liao, Hsin-Wei 
AU  - Hung, Mien-Chie  
VL  - 7
IS  - 11
PY  - 2017
DA  - 2017/06/05
SP  - e2311
C1  - Bio-protocol 2017;7:e2311
DO  - 10.21769/BioProtoc.2311
UR  - https://doi.org/10.21769/BioProtoc.2311
AB  - The host microenvironment plays a prominent role in tumor growth, angiogenesis, invasion, metastasis, and response to therapy. Orthotopic tumor model mimics the natural environment of tumor development and provides an effective approach to investigate tumor pathophysiology and develop therapeutic strategies. This protocol describes the technique involving injection of colorectal cancer cell suspension into the intestinal wall of mice to establish an orthotopic colorectal tumor model.
KW  - Colorectal cancer
KW  - Orthotopic model
KW  - Cecum
KW  - Ascending colon
KW  - Nude mice
JF  - Bio-protocol
SN  - 2331-8325
PB  - Bio-protocol LLC.
BIO101  - False