TY  - JOUR
TI  - In vivo Mitophagy Monitoring in Caenorhabditis elegans to Determine Mitochondrial Homeostasis
AU  - Palikaras, Konstantinos 
AU  - Tavernarakis, Nektarios  
VL  - 7
IS  - 7
PY  - 2017
DA  - 2017/04/05
SP  - e2215
C1  - Bio-protocol 2017;7:e2215
DO  - 10.21769/BioProtoc.2215
UR  - https://doi.org/10.21769/BioProtoc.2215
AB  - Perturbation of mitochondrial function is a major hallmark of several pathological conditions and ageing, underlining the essential role of fine-tuned mitochondrial activity (Lopez-Otin et al., 2013). Mitochondrial selective autophagy, known as mitophagy, mediates the removal of dysfunctional and/or superfluous organelles, preserving cellular and organismal homeostasis (Palikaras and Tavernarakis, 2014; Pickrell and Youle, 2015; Scheibye-Knudsen et al., 2015). In this protocol, we describe a method for assessing mitophagy in the nematode Caenorhabditis elegans.
KW  - Ageing
KW  - Autophagosome
KW  - Autophagy
KW  - Caenorhabditis elegans
KW  - Lysosomes
KW  - Mitochondria
KW  - Mitophagy
KW  - mtRosella
JF  - Bio-protocol
SN  - 2331-8325
PB  - Bio-protocol LLC.
BIO101  - False