TY  - JOUR
TI  - Testing Depression in Mice: a Chronic Social Defeat Stress Model
AU  - Kim, Hee-Dae  
AU  - Call, Tanessa  
AU  - Carotenuto, Samantha  
AU  - Johnson, Ross  
AU  - Ferguson, Deveroux  
VL  - 7
IS  - 7
PY  - 2017
DA  - 2017/04/05
SP  - e2203
C1  - Bio-protocol 2017;7:e2203
DO  - 10.21769/BioProtoc.2203
UR  - https://doi.org/10.21769/BioProtoc.2203
AB  - A vast challenge within neuropsychiatric research has been the development of animal models that accurately reflect symptoms associated with affective disorders. An ethologically valid model that has been shown to be effective in studying depression is the chronic social defeat stress model. In this model, C57BL/6J mice are subjected to chronic social defeat stress induced by CD-1 aggressor mice for 10 consecutive days. Discussed here is a protocol describing the screening process of the CD-1 aggressor mice, the confrontations between the C57BL/6J and CD-1 aggressor mice, and analysis of social avoidance scores as an indication of depression-like behaviors.
KW  - Social defeat
KW  - Depression
KW  - Chronic stress
KW  - Social interaction
KW  - Mouse model
JF  - Bio-protocol
SN  - 2331-8325
PB  - Bio-protocol LLC.
BIO101  - False