TY  - JOUR
TI  - High Fat Diet-induced Breast Cancer Model in Rat
AU  - Wu, Meng Ju
AU  - Chang, Chun Ju
VL  - 6
IS  - 13
PY  - 2016
DA  - 2016/07/05
SP  - e1852
C1  - Bio-protocol 2016;6:e1852
DO  - 10.21769/BioProtoc.1852
UR  - https://doi.org/10.21769/BioProtoc.1852
AB  - Obesity has been linked to breast cancer progression but the underlying mechanisms remain obscure. Being overweight or obese for a woman at the time she is diagnosed with breast cancer is linked to a high risk of recurrence regardless of treatment factors. In rodents, high body weight is also associated with increased incidence of spontaneous and chemically induced tumors. To study the complex interaction between the mammary epithelia and the microenvironment, with a focus on the mechanism underlying the role obesity plays in the regulation of the cancer stem cell traits and the development of mammary cancer in vivo, we have established a diet-induced obesity (DIO) rat model of breast cancer (Chang et al., 2015).
KW  - Obesity
KW  - High-fat diet
KW  - Breast cancer
JF  - Bio-protocol
SN  - 2331-8325
PB  - Bio-protocol LLC.
BIO101  - False