TY  - JOUR
TI  - Protocol for Macrophage Depletion from Mice
AU  - Xiao, Zuoxiang  
AU  - Jiang, Qun 
VL  - 4
IS  - 11
PY  - 2014
DA  - 2014/06/05
SP  - e1144
C1  - Bio-protocol 2014;4:e1144
DO  - 10.21769/BioProtoc.1144
UR  - https://doi.org/10.21769/BioProtoc.1144
AB  - Macrophage depletion has been used extensively to study autoimmune disease and more recently in tumor models. The clodronate-containing liposomes will be recognized as foreign particles and get engulfed by macrophages upon dosing into the animal by the chosen routes. Consequently, macrophages that have engulfed liposomes will all be destroyed by the liposomal. In the protocol presented here the clodronate-containing liposomes were used to systemically deplete macrophages in mice.
JF  - Bio-protocol
SN  - 2331-8325
PB  - Bio-protocol LLC.
BIO101  - False