Natalie Sims St. Vincent's Institute of Medical Research
1 protocol

Ingrid Poulton 1 protocol

Narelle McGregor Bone Biology, St Vincent's Institute, 2006-2020
1 protocol

Emma C Walker
  • Research Assistant, Bone Biology, St Vincent's Institute, 2001-2020
Research focus
  • -
  • 1 Author merit

Education

Honours, Deakin University , Australia, 2000

Publications

• McGregor, N. E., Murat, M., Elango, J., Poulton, I. J., Walker, E. C., Crimeen-Irwin, B., Ho, P. W. M., Gooi, J. H., Martin, T. J. and Sims, N. A. (2019). IL-6 exhibits both cis- and trans-signaling in osteocytes and osteoblasts, but only trans-signaling promotes bone formation and osteoclastogenesis. J Biol Chem 294(19): 7850-7863.
• Cho, D. C., Brennan, H. J., Johnson, R. W., Poulton, I. J., Gooi, J. H., Tonkin, B. A., McGregor, N. E., Walker, E. C., Handelsman, D. J., Martin, T. J. and Sims, N. A. (2017). Bone corticalization requires local SOCS3 activity and is promoted by androgen action via interleukin-6. Nat Commun 8(1): 806.
• Walker, E. C., Johnson, R. W., Hu, Y., Brennan, H. J., Poulton, I. J., Zhang, J. G., Jenkins, B. J., Smyth, G. K., Nicola, N. A. and Sims, N. A. (2016). Murine Oncostatin M Acts via Leukemia Inhibitory Factor Receptor to Phosphorylate Signal Transducer and Activator of Transcription 3 (STAT3) but Not STAT1, an Effect That Protects Bone Mass. J Biol Chem 291(41): 21703-21716.
• Johnson, R. W., White, J. D., Walker, E. C., Martin, T. J. and Sims, N. A. (2014). Myokines (muscle-derived cytokines and chemokines) including ciliary neurotrophic factor (CNTF) inhibit osteoblast differentiation. Bone 64: 47-56.
• Johnson, R. W., Brennan, H. J., Vrahnas, C., Poulton, I. J., McGregor, N. E., Standal, T., Walker, E. C., Koh, T. T., Nguyen, H., Walsh, N. C., Forwood, M. R., Martin, T. J. and Sims, N. A. (2014). The primary function of gp130 signaling in osteoblasts is to maintain bone formation and strength, rather than promote osteoclast formation. J Bone Miner Res 29(6): 1492-1505.
• Poulton, I. J., McGregor, N. E., Pompolo, S., Walker, E. C. and Sims, N. A. (2012). Contrasting roles of leukemia inhibitory factor in murine bone development and remodeling involve region-specific changes in vascularization. J Bone Miner Res 27(3): 586-595.
• Quach, J. M., Walker, E. C., Allan, E., Solano, M., Yokoyama, A., Kato, S., Sims, N. A., Gillespie, M. T. and Martin, T. J. (2011). Zinc finger protein 467 is a novel regulator of osteoblast and adipocyte commitment. J Biol Chem 286(6): 4186-4198.
• McGregor, N. E., Poulton, I. J., Walker, E. C., Pompolo, S., Quinn, J. M., Martin, T. J. and Sims, N. A. (2010). Ciliary neurotrophic factor inhibits bone formation and plays a sex-specific role in bone growth and remodeling. Calcif Tissue Int 86(3): 261-270.
• Walker, E. C., McGregor, N. E., Poulton, I. J., Solano, M., Pompolo, S., Fernandes, T. J., Constable, M. J., Nicholson, G. C., Zhang, J. G., Nicola, N. A., Gillespie, M. T., Martin, T. J. and Sims, N. A. (2010). Oncostatin M promotes bone formation independently of resorption when signaling through leukemia inhibitory factor receptor in mice. J Clin Invest 120(2): 582-592.
• Quinn, J. M., Sims, N. A., Saleh, H., Mirosa, D., Thompson, K., Bouralexis, S., Walker, E. C., Martin, T. J. and Gillespie, M. T. (2008). IL-23 inhibits osteoclastogenesis indirectly through lymphocytes and is required for the maintenance of bone mass in mice. J Immunol 181(8): 5720-5729.
• Kartsogiannis, V., Sims, N. A., Quinn, J. M., Ly, C., Cipetic, M., Poulton, I. J., Walker, E. C., Saleh, H., McGregor, N. E., Wallace, M. E., Smyth, M. J., Martin, T. J., Zhou, H., Ng, K. W. and Gillespie, M. T. (2008). Osteoclast inhibitory lectin, an immune cell product that is required for normal bone physiology in vivo. J Biol Chem 283(45): 30850-30860.
• Walker, E. C., McGregor, N. E., Poulton, I. J., Pompolo, S., Allan, E. H., Quinn, J. M., Gillespie, M. T., Martin, T. J. and Sims, N. A. (2008). Cardiotrophin-1 is an osteoclast-derived stimulus of bone formation required for normal bone remodeling. J Bone Miner Res 23(12): 2025-2032.
• Udabage, L., Brownlee, G. R., Waltham, M., Blick, T., Walker, E. C., Heldin, P., Nilsson, S. K., Thompson, E. W. and Brown, T. J. (2005). Antisense-mediated suppression of hyaluronan synthase 2 inhibits the tumorigenesis and progression of breast cancer. Cancer Res 65(14): 6139-6150.
• Lafleur, M. A., Drew, A. F., de Sousa, E. L., Blick, T., Bills, M., Walker, E. C., Williams, E. D., Waltham, M. and Thompson, E. W. (2005). Upregulation of matrix metalloproteinases (MMPs) in breast cancer xenografts: a major induction of stromal MMP-13. Int J Cancer 114(4): 544-554.
• Tester, A. M., Waltham, M., Oh, S. J., Bae, S. N., Bills, M. M., Walker, E. C., Kern, F. G., Stetler-Stevenson, W. G., Lippman, M. E. and Thompson, E. W. (2004). Pro-matrix metalloproteinase-2 transfection increases orthotopic primary growth and experimental metastasis of MDA-MB-231 human breast cancer cells in nude mice. Cancer Res 64(2): 652-658.
1 Protocol published
Testing Bone Formation Induction by Calvarial Injection Assay in vivo
Authors:  Narelle E McGregor, Ingrid J Poulton, Emma C Walker and Natalie A Sims, date: 03/20/2020, view: 308, Q&A: 0
Bone formation occurs during embryogenesis, skeletal growth and during the process of skeletal renewal throughout life. In the process of bone formation, osteoblasts lay down a collagen-containing matrix, termed osteoid, which is gradually hardened ...
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