Prasanth Manohar
  • Post-Doc, Zhejiang University, Zhejiang University-University of Edinburgh (ZJU-UoE)
Research focus
  • Microbiology
  • Phage therapy, Antibiotic resistance in Gram-negative bacteria, bacteriophage biology

Education

PhD, Vellore Institute of Technology, 2019

Lab information

@Leptihnlab
https://leptihn-lab.org/the-research/

Publications

https://scholar.google.co.in/citations?user=Bd2Eo7YAAAAJ&hl=en
• Application of bacteriophages and endolysins as a biocontrol measure. Ramesh N, Madhav MR, Manohar P, Leptihn S. Biological Control, 160, 2021.
• Encapsulation and Delivery of Therapeutic phages. Loh B, Gondil VS, Manohar P, Khan FM, Yang H, Leptihn S. Applied and Environmental Microbiology, 87(5), 2021.
• Dissemination of carbapenem-resistance and plasmids-encoding carbapenemases in Gram-negative bacteria isolates from India. Manohar P, Leptihn S, Lopes BS, Nachimuthu R. JAC-Antimicrobial Resistance, 3(1), dlab015, 2021.
• Reduced Metagenomic sequencing (RMS) approach to determine the gut-associated phageome in mother-child. Manohar P, Ramesh N, Leptihn S, Ravi A, Rudi K. Human Microbiome Journal, 19, 100078, 2021.
• Morphological characterization techniques for the isolation of virulent bacteriophages from environmental sources. Manohar P, Kandasamy E, Loganathan A, Madurantakam R. M, Sebastian L, Nachimuthu R. International Journal of Bacteriophage Research, 1:1-9, 2021.
• Effect of phage lifestyle on the plaque morphology. Archana L, Manohar P, Sebastian L, Nachimuthu R. International Journal of Bacteriophage Research, 1:10-15, 2021.
• Assessing the efficacy of phage-cocktail and phage-antibiotic combinations against Enterotoxigenic Escherichia coli using a Galleria mellonella infection model. Manohar P, Loganathan A, Belinda L, Sebastian L, Nachimuthu R. International Journal of Bacteriophage Research, 1:16-20, 2021.
• Ramesh N, Manohar P, Archana L, Eniyan K, Leptihn S. Phage therapy as an alternative antibacterial therapy. Frontiers in Anti-Infective Agents. [Bentham Science publishers], 19(5), 2021. (accepted)
• A Biological Inventory of Prophages in A. baumannii Genomes Reveal Distinct Distributions in Classes, Length and Genomic Positions. Loh B, Chen J, Manohar P, Yu Y, Hua X, Leptihn S. Frontiers in Microbiology, 11:579802, 2020.
• Will the overuse of antibiotics during the coronavirus pandemic accelerate antimicrobial resistance of bacteria? Manohar P, Loh B, Leptihn S. Infectious Microbes & Diseases, 2(3), 2020.
• Secondary bacterial infections in patients with viral pneumoniae. Manohar P, Loh B, Nachimuthu R, Hua X, Welburn SC, Leptihn C. Frontiers in Medicine, 7:420, 2020.
• Secondary bacterial infections during pulmonary viral diseases: Phage therapeutics as alternatives to antibiotics? Manohar P, Loh B, Athira S, Nachimuthu R, Hua X, Welburn SC, Leptihn C. Frontiers in Microbiology, 11, 1434, 2020.
• CTX-M-type ESBL-mediated resistance to third-generation cephalosporins and conjugative transfer of resistance in Gram-negative bacteria isolated from hospitals in Tamil Nadu, India. Nachimuthu R, Kannan VR, Bozdogan B, Krishnakumar V, Pandiyan KS, Manohar P. Access Microbiology, 2020.
• Characterization and genome analysis of B1 sub-cluster mycobacteriophage PDRPxv. Sinha A, Eniyan K, Manohar P, Ramesh N, Bajpai U. Virus Research, 197884, 2020.
• Manohar P, Shanthini, T, Bozdogan B, Lundborg CS, Tamhankar AJ, Palaniyar N, Ramesh N. Transfer of antibiotic resistance genes from Gram-positive bacterium to Gram-negative bacterium. BioRxiv, 2020.
• Manohar P, Leptihn S, Lopes BS, Ramesh N. Dissemination of carbapenem resistance and plasmids-encoding carbapenemases in Gram-negative bacteria isolated from India. BioRxiv, 2020.
• Manohar P, Joseph A, Karthika B, AnuPriya P, Mani SS, Varsha VS, Ramesh N. Detection of NDM-1, VIM-1 and AIM-type Metallo-beta-lactamase genes in Gram-negative bacteria isolated from clinical samples in Tamil Nadu. BioRxiv, 2020.
• Loh B, Chen J, Manohar P, Yu Y, Hua X, Leptihn S. A Biological Inventory of Prophages in A. baumannii Genomes Reveal Distinct Distributions in Classes, Length and Genomic Positions. BioRxiv, 2020.
• Improved lyophilization conditions for long-term storage of bacteriophages. Manohar P and Ramesh N. Scientific Reports, 2019, 9(1).
• Therapeutic characterization and efficacy of bacteriophage cocktails infecting Escherichia coli, Klebsiella pneumoniae and Enterobacter species. Manohar P, Tamhankar AJ, Lundborg CS, Nachimuthu R. Frontiers in Microbiology, 2019; 10, 574.
• Evaluation of various phenotypic methods with genotypic screening for detection of methicillin-resistant Staphylococcus aureus. Archana L, Manohar P, Eniyan K, Jayaraj R, N Ramesh. Asian Biomedicine, 13(6), 2019.
• Emergence of plasmid-borne blaoxa-181 gene in Ochrobactrum intermedium: first report from India. Shanthini T, Manohar P, Samna S et al. Access Microbiology, 1(3), 2019.
• Effect of various bacteriological media on the plaque morphology of Staphylococcus and Vibrio phages. Ramesh N, Archana L, Royam MM, Manohar P, Eniyan K. Access Microbiology, 2019, 1(4).
• Synthesis, characterisation, molecular docking, biomolecular interaction and cytotoxicity studies of novel ruthenium (ii)–arene-2-heteroarylbenzoxazole complexes. De S, Chaudhuri SR, Panda A, Jadhav GR, Kumar RS, Manohar P, Ramesh N et al. New Journal of Chemistry, 2019.
• Pharmacological and immunological aspects of phage therapy. Manohar P, Tamhankar AJ, Leptihn S, Ramesh N. Infectious Microbes & Diseases, 1:2, 2019.
• Manohar P, Ragavi M, Ashby A et al. First report of blaGIM-1 in Acinetobacter variabilis isolated from hospital samples. BioRxiv, 2019.
• Isolation, characterization and in vivo efficacy of Escherichia phage myPSH1131. Manohar P, Tamhankar AJ, Cecilia SL, Ramesh N. PLoS One, 2018; 13(10): e0206278.
• The therapeutic potential of bacteriophages targeting Gram-negative bacteria using Galleria mellonella infection model. Manohar P, Ramesh N, Lopes BS. BMC Microbiology, 2018, 18:97.
• Identification of blaDIM-1 metallo beta-lactamase in Pseudomonas aeruginosa isolated From Tamil Nadu, India. Manohar P, Babu S, Bozdogan B et al. Journal of Global Antimicrobial Resistance, 2018, 13, 7-8.
• Evaluation of phenotypic methods used for the detection of carbapenemase: modified Hodge test, carbapenem inactivation method, and carbaNP test. Manohar P, Nazia Hassan, Abha Kumari, Vaikhari Kale, Ramesh N. Romanian Archives of Microbiology and Immunology. 77 (2), 2018, 141-147.
• Comparison of reduced metagenome and 16S rRNA gene sequencing for determination of genetic diversity and mother-child overlap of the gut associated microbiota. Ravi A, Avershina E,.. Manohar P, N Ramesh, Rudi K. Journal of Microbiological Methods, 149, 44-52, 2018.
• Colistin-resistant Klebsiella pneumoniae: prevalence of integrons and synergistic out turn for colistin-meropenem. Manohar P, Shanthini T, Ekta P et al. Archives of Clinical Infectious Diseases, 13(1), 2018, e55099.
• Bacterial Load and Contamination of Indian Currency Note: Isolation and Transferability Studies of Multi-Drug Resistant Bacteria. Manohar P, Shanthini T, Goswami P et al. Indian Journal of Public Health Research and Development, 9(9), 2018.
• Manohar P, Shanthini T, Reethu Ann Philip et al. Role of biofilm-specific antibiotic resistance genes PA0756-0757, PA5033 and PA2070 in Pseudomonas aeruginosa. BioRxiv, 2018.
• The distribution of carbapenem- and colistin- resistance in Gram-negative bacteria from Tamil Nadu region in India. Manohar P, T Shanthini, Ramankannan A et al. Journal of Medical Microbiology, 2017, 66, 874-883.
• Genetic Characteristics of Plasmid-Mediated Extended Spectrum Beta-Lactamases and Its Coexistence with NDM-1 in Clinical Gram-negative Bacteria. Manohar P, Shanthini T, Marathe N et al. Indian Journal of Biotechnology, 2017, 16(2), 189-194.
• Preparation of nanocrystalline forsterite by combustion of different fuels and their comparative in-vitro bioactivity, dissolution behaviour and antibacterial studies. Choudhary R, Manohar P, Jana Vecstaudza et al. Materials Science and Engineering C, 2017, 77, 811–822.
• Enhanced Amylolytic Activity of Intracellular Α-Amylase Produced By Bacillus tequilensis. Manohar P, T Shanthini, KM Gothandam et al. The Journal of Microbiology, Biotechnology and Food Sciences, 2017, 6 (6). 1314.
• Nano-antibiotics: A therapeutic future. Ramesh N, Manohar P, Shanthini T et al. Nanoscience and Nanotechnology-Asia, 2017, 7 (1), 3-25.
• Anuradha Ravi, Ekaterina Avershina…, Manohar P, Sumathi Padmanaban, Ramesh N, Knut Rudi. Genetic diversity and mother-child overlap of the gut associated microbiota determined by reduced genome sequencing. BioRxiv, 2017.
• Characterization of carbapenem resistant Gram negative bacteria from Tamil Nadu. Nachimuthu R, Karthikeyan S, Manohar P, Bozdogan B. Journal of Chemotherapy, 2016, 28(5), 371-374.
• Colistin susceptibility of Gram-negative clinical isolates in Tamil Nadu, India. Nachimuthu R, Manohar P, Subramani R et al. Asian Biomedicine, 2016, 10(1), 1-3.
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