Jim Reed Division of Biological Sciences, University of Montana, Missoula
1 protocol

Scott A. Wetzel
  • Faculty, Division of Biological Sciences and Center for Environmental Health Sciences, University of Montana, Missoula
Research focus
  • -
  • 1 Author merit

Education

Ph.D., Oregon HealthSciences University, 2001

Lab information

http://hs.umt.edu/dbs/labs/wetzel/default.php

Publications

https://orcid.org/0000-0001-6843-4583
• Reed, J. and Wetzel, S. A. (2019). Trogocytosis-Mediated Intracellular Signaling in CD4+ T Cells Drives TH2-Associated Effector Cytokine Production and Differentiation. J Immunol 202(10): 2873-2887.
• Reed, J. and Wetzel, S. A. (2018). CD4+ T Cell Differentiation and Activation. Methods Mol Biol 1803: 335-351.
• Thueson, L. E., Emmons, T. R., Browning, D. L., Kreitinger, J. M., Shepherd, D. M. and Wetzel, S. A. (2015). In vitro exposure to the herbicide atrazine inhibits T cell activation, proliferation, and cytokine production and significantly increases the frequency of Foxp3+ regulatory T cells. Toxicol Sci 143(2): 418-429.
• Osborne, D. G. and Wetzel, S. A. (2012). Trogocytosis results in sustained intracellular signaling in CD4+ T cells. J Immunol 189(10): 4728-4739.
• Doherty, M., Osborne, D. G., Browning, D. L., Parker, D. C. and Wetzel, S. A. (2010). Anergic CD4+ T cells form mature immunological synapses with enhanced accumulation of c-Cbl and Cbl-b. J Immunol 184(7): 3598-3608.
• Thauland, T. J., Koguchi, Y., Wetzel, S. A., Dustin, M. L. and Parker, D. C. (2008). Th1 and Th2 cells form morphologically distinct immunological synapses. J Immunol 181(1): 393-399.
• Blake, D. J., Wetzel, S. A. and Pfau, J. C. (2008). Autoantibodies from mice exposed to Libby amphibole asbestos bind SSA/Ro52-enriched apoptotic blebs of murine macrophages. Toxicology 246(2-3): 172-179.
• Wetzel, S. A. and Parker, D. C. (2006). MHC transfer from APC to T cells following antigen recognition. Crit Rev Immunol 26(1): 1-21.
• Dillon, T. J., Carey, K. D., Wetzel, S. A., Parker, D. C. and Stork, P. J. (2005). Regulation of the small GTPase Rap1 and extracellular signal-regulated kinases by the costimulatory molecule CTLA-4. Mol Cell Biol 25(10): 4117-4128.
• Wetzel, S. A., McKeithan, T. W. and Parker, D. C. (2005). Peptide-specific intercellular transfer of MHC class II to CD4+ T cells directly from the immunological synapse upon cellular dissociation. J Immunol 174(1): 80-89.
• Dillon, T. J., Karpitski, V., Wetzel, S. A., Parker, D. C., Shaw, A. S. and Stork, P. J. (2003). Ectopic B-Raf expression enhances extracellular signal-regulated kinase (ERK) signaling in T cells and prevents antigen-presenting cell-induced anergy. J Biol Chem 278(38): 35940-35949.
• Wetzel, S. A. and Parker, D. C. (2006). MHC transfer from APC to T cells following antigen recognition. Crit Rev Immunol 26(1): 1-21.
• Wetzel, S. A. (2001). Imaging and analysis of the immunological synapse formed between CD4+ T Lymphocytes and antigen presenting cells. Ph.D. Thesis, Oregon Health Sciences University
• Sperry, P. J., Cua, D. J., Wetzel, S. A. and Adler-Moore, J. P. (1998). Antimicrobial activity of AmBisome and non-liposomal amphotericin B following uptake of Candida glabrata by murine epidermal Langerhans cells. Med Mycol 36(3): 135-141.
• Primus, F. J., Finch, M. D., Wetzel, S. A., Masci, A. M., Schlom, J. and Kashmiri, S. V. (1994). Monoclonal antibody gene transfer. Implications for tumor-specific cell-mediated cytotoxicity. Ann N Y Acad Sci 716: 154-165; discussion 165-156.
1 Protocol published
Assessing in vitro and in vivo Trogocytosis By Murine CD4+ T cells
Authors:  Jim Reed and Scott A. Wetzel, date: 05/05/2020, view: 880, Q&A: 0
Recognition of antigens by lymphocytes (B, T, and NK) on the surface of an antigen-presenting cell (APC) leads to lymphocyte activation and the formation of an immunological synapse between the lymphocyte and the APC. At the immunological synapse ...
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