Jennifer Philips Department of Medicine, Division of Infectious Diseases, New York University School of Medicine, USA
1 protocol
Achille Broggi Harvard Medical School
15 protocols

Alexandros Kokotos Weill Cornell Medicine
13 protocols

Amit Dey International Centre for Genetic Engineering and Biotechnology
13 protocols

Amriti Lulla UT MD Anderson Cancer Center
6 protocols

Editor
Alka Mehra
  • Research scientist, Institute of Genomics and Integrative Biology
Research focus
  • Microbiology
  • host-pathogen interactions, macrophages, innate immunity, microbiology, cellular trafficking pathways, signaling, microRNAs.
  • 2 Author merit

Education

Ph.D., Jawaharlal Nehru University

Publications

1. Portal-Celhay C, Tufariello JM, Srivastava S, Zahra A, Klevorn T, Grace PS, Mehra A, Park HS, Ernst JD, Jacobs Jr. WR, and Philips JA. (2016) Mycobacterium tuberculosis EsxH inhibits ESCRT-dependent CD4+ T cell activation. Nature Microbiology Dec5 (2) 16232.

2. Mehra A. (2015). Microbial CRISPR-Cas System: From Bacterial Immunity to Next-Generation Antimicrobials. Microbial Factories (Springer India 2015, ISBN No.: 978-81-322-2594-2) Volume 2, Chapter 14. 217-234. DOI: 10.1007/978-81-322-2595-9_14.

3. Mehra A. (2014). Phagolysosomal Trafficking Assay. Bio-protocol 4 (13) e1163; DOI: https://dx.doi.org/10.21769/BioProtoc.1163.

4. Mehra A* and Philips JA*. (2014). Analysis of Mycobacterial Protein Secretion. Bio-protocol 4 (12) e1159; *Co-corresponding author. DOI: https://dx.doi.org/10.21769/BioProtoc.1159.

5. Siegrist MS, Steigedal M, Ahmad R, Mehra A, Dragset MS, Schuster BM, Philips JA, Carr SA, Rubin EJ. (2014). Mycobacterial Esx-3 requires multiple components for iron acquisition. mBio. 5 (3) e01073-14.

6. Mehra A*, Zahra A*, Thompson V, Sirisaengtaksin N, Wells A, Porto M, Köster S, Penberthy K, Kubota Y, Dricot A, Rogan D, Vidal M, Bean AJ, Hill D, Philips JA. (2013). Mycobacterium tuberculosis type VII secreted effector, EsxH targets host ESCRT to inhibit intracellular trafficking. PLOS Pathogens. 9(10) e100373. * Equal contribution.

7. Singh Y, Kaul V, Mehra A, Chatterjee S, Tousif S, Dwivedi VP, Suar M, Kaer LV, Bishai WR and Das G. (2013). Mycobacterium tuberculosis controls miR99b expression in infected murine dendritic cells to modulate host immunity. Journal of Biological Chemistry. Feb 15; 288(7): 5056-61.

8. Juranek J, Kothary P, Mehra A, Hays A, Brannagan III TH, Schmidt AM. (2013). Increased expression of the Receptor for Advanced End-Glycation Products in the neuropathic peripheral nerve of human patients. Brain and Behaviour. 3(6) 701-709.

9. Mehra A, Bhattacharya S and Bhattacharya A. (2007). Identification of a novel lysine rich protein from Entamoeba histolytica. American J Biochemistry and Biotechnology. 3(4): 193-198.

10. Mehra A, Fredrick J, Petri WA Jr, Bhattacharya S and Bhattacharya A. (2006). Expression and function of a family of transmembrane kinases from the protozoan parasite Entamoeba histolytica. Infect and Immun. Sep; 74(9): 5341-51.

11. Arya R, Mehra A, Bhattacharya S, Vishwakarma RA and Bhattacharya A. (2003). Biosynthesis of Entamoeba histolytica Proteophosphoglycan in vitro. Mol. Biochem. Parasitol. Jan, 126 (1): 1-8.
2 Protocols published
Phagolysosomal Trafficking Assay
Author:  Alka Mehra, date: 07/05/2014, view: 11630, Q&A: 0
Phagolysosomal trafficking is an important innate defense pathway that clears microbes by delivering them to lysosomes, the degradative compartment of the cell. Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis, subverts ...
Analysis of Mycobacterial Protein Secretion
Authors:  Alka Mehra and Jennifer A. Philips, date: 06/20/2014, view: 10137, Q&A: 0
Mycobacterium tuberculosis (Mtb) is the causative agent of tuberculosis. Analysis of proteins secreted by Mtb has been of interest to the field of tuberculosis research since certain secreted proteins interact with the host to promote ...
8 Protocols reviewed
Adoptive Transfer of Monocytes Sorted from Bone Marrow
Authors:  Damya Laoui, Eva Van Overmeire, Chloé Abels, Jiri Keirsse and Jo A Van Ginderachter, date: 01/05/2019, view: 3312, Q&A: 0
Inflammatory Ly6Chi monocytes can give rise to distinct mononuclear myeloid cells in the tumor microenvironment, such as monocytic myeloid-derived suppressor cells (Mo-MDSC), immature macrophages, M2-like tumor-associated macrophages ...
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In vivo Imaging of Tumor and Immune Cell Interactions in the Lung
Authors:  Richard N. Hanna, Grzegorz Chodaczek and Catherine C. Hedrick, date: 10/20/2016, view: 5928, Q&A: 0
Immunotherapy has demonstrated great therapeutic potential by activating the immune system to fight cancer. However, little is known about the specific dynamics of interactions that occur between tumor and immune cells. In this protocol we describe ...
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26 Protocols edited
Analysis of Generalized Fibrosis in Mouse Tissue Sections with Masson’s Trichrome Staining
Authors:  Diantha van de Vlekkert, Eda Machado and Alessandra d’Azzo, date: 05/20/2020, view: 677, Q&A: 0
Expansion of fibrous connective tissue and abnormal deposition of extracellular matrix (ECM) are at the basis of many fibrotic diseases. Fibrosis can occur in response to both physiological and pathological cues, including wound healing, tissue ...
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Isolation, Purification and Characterization of Exosomes from Fibroblast Cultures of Skeletal Muscle
Authors:  Diantha van de Vlekkert, Xiaohui Qiu, Ida Annunziata and Alessandra d'Azzo, date: 04/05/2020, view: 576, Q&A: 0
Exosomes are dynamic nanovesicles secreted by virtually all cells and are present in all biological fluids. Given their highly heterogeneous content exosomes have been implicated in many physiological and pathological processes that they exert by ...
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