Jennifer Philips Department of Medicine, Division of Infectious Diseases, New York University School of Medicine, USA
1 protocol
Achille Broggi Harvard Medical School
14 protocols

Alexandros Kokotos Weill Cornell Medicine
10 protocols

Amriti Lulla UT MD Anderson Cancer Center
6 protocols

Andrea Introini Karolinska Institutet
8 protocols

Editor
Alka Mehra
  • Research scientist, Institute of Genomics and Integrative Biology
Research focus
  • Immunology
  • host-pathogen interactions, macrophages, innate immunity
  • 2 Author merit

Education

Ph.D., Jawaharlal Nehru University, 2006

Publications

1. Portal-Celhay C, Tufariello JM, Srivastava S, Zahra A, Klevorn T, Grace PS, Mehra A, Park HS, Ernst JD, Jacobs Jr. WR, and Philips JA. (2016) Mycobacterium tuberculosis EsxH inhibits ESCRT-dependent CD4+ T cell activation. Nature Microbiology Dec5 (2) 16232.

2. Mehra A. (2015). Microbial CRISPR-Cas System: From Bacterial Immunity to Next-Generation Antimicrobials. Microbial Factories (Springer India 2015, ISBN No.: 978-81-322-2594-2) Volume 2, Chapter 14. 217-234. DOI: 10.1007/978-81-322-2595-9_14.

3. Mehra A. (2014). Phagolysosomal Trafficking Assay. Bio-protocol 4 (13) e1163; DOI: https://dx.doi.org/10.21769/BioProtoc.1163.

4. Mehra A* and Philips JA*. (2014). Analysis of Mycobacterial Protein Secretion. Bio-protocol 4 (12) e1159; *Co-corresponding author. DOI: https://dx.doi.org/10.21769/BioProtoc.1159.

5. Siegrist MS, Steigedal M, Ahmad R, Mehra A, Dragset MS, Schuster BM, Philips JA, Carr SA, Rubin EJ. (2014). Mycobacterial Esx-3 requires multiple components for iron acquisition. mBio. 5 (3) e01073-14.

6. Mehra A*, Zahra A*, Thompson V, Sirisaengtaksin N, Wells A, Porto M, Köster S, Penberthy K, Kubota Y, Dricot A, Rogan D, Vidal M, Bean AJ, Hill D, Philips JA. (2013). Mycobacterium tuberculosis type VII secreted effector, EsxH targets host ESCRT to inhibit intracellular trafficking. PLOS Pathogens. 9(10) e100373. * Equal contribution.

7. Singh Y, Kaul V, Mehra A, Chatterjee S, Tousif S, Dwivedi VP, Suar M, Kaer LV, Bishai WR and Das G. (2013). Mycobacterium tuberculosis controls miR99b expression in infected murine dendritic cells to modulate host immunity. Journal of Biological Chemistry. Feb 15; 288(7): 5056-61.

8. Juranek J, Kothary P, Mehra A, Hays A, Brannagan III TH, Schmidt AM. (2013). Increased expression of the Receptor for Advanced End-Glycation Products in the neuropathic peripheral nerve of human patients. Brain and Behaviour. 3(6) 701-709.

9. Mehra A, Bhattacharya S and Bhattacharya A. (2007). Identification of a novel lysine rich protein from Entamoeba histolytica. American J Biochemistry and Biotechnology. 3(4): 193-198.

10. Mehra A, Fredrick J, Petri WA Jr, Bhattacharya S and Bhattacharya A. (2006). Expression and function of a family of transmembrane kinases from the protozoan parasite Entamoeba histolytica. Infect and Immun. Sep; 74(9): 5341-51.

11. Arya R, Mehra A, Bhattacharya S, Vishwakarma RA and Bhattacharya A. (2003). Biosynthesis of Entamoeba histolytica Proteophosphoglycan in vitro. Mol. Biochem. Parasitol. Jan, 126 (1): 1-8.
2 Protocols published
Phagolysosomal Trafficking Assay
Author:  Alka Mehra, date: 07/05/2014, view: 10958, Q&A: 0
Phagolysosomal trafficking is an important innate defense pathway that clears microbes by delivering them to lysosomes, the degradative compartment of the cell. Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis, subverts ...
Analysis of Mycobacterial Protein Secretion
Authors:  Alka Mehra and Jennifer A. Philips, date: 06/20/2014, view: 9594, Q&A: 0
Mycobacterium tuberculosis (Mtb) is the causative agent of tuberculosis. Analysis of proteins secreted by Mtb has been of interest to the field of tuberculosis research since certain secreted proteins interact with the host to promote ...
8 Protocols reviewed
Adoptive Transfer of Monocytes Sorted from Bone Marrow
Authors:  Damya Laoui, Eva Van Overmeire, Chloé Abels, Jiri Keirsse and Jo A Van Ginderachter, date: 01/05/2019, view: 2241, Q&A: 0
Inflammatory Ly6Chi monocytes can give rise to distinct mononuclear myeloid cells in the tumor microenvironment, such as monocytic myeloid-derived suppressor cells (Mo-MDSC), immature macrophages, M2-like tumor-associated macrophages ...
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In vivo Imaging of Tumor and Immune Cell Interactions in the Lung
Authors:  Richard N. Hanna, Grzegorz Chodaczek and Catherine C. Hedrick, date: 10/20/2016, view: 5469, Q&A: 0
Immunotherapy has demonstrated great therapeutic potential by activating the immune system to fight cancer. However, little is known about the specific dynamics of interactions that occur between tumor and immune cells. In this protocol we describe ...
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22 Protocols edited
Automated Analysis of Cell Surface Ruffling: Ruffle Quantification Macro
Authors:  Nicholas D. Condon, Jennifer L. Stow and Adam A. Wall, date: 01/20/2020, view: 19, Q&A: 0
Cell surface protrusions include F-actin rich, wave-like ruffles that are erected transiently in response to stimuli and during cell migration. Macrophages are innate immune cells that ruffle constitutively and more dramatically in cells activated ...
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Propagation and Purification of Chlamydia trachomatis Serovar L2 Transformants and Mutants
Authors:  Robert Faris and Mary M. Weber, date: 12/20/2019, view: 281, Q&A: 0
Chlamydia trachomatis (C.t.) is an obligate intracellular pathogen that cannot be cultured axenically and must be propagated within eukaryotic host cells. There are at least 15 distinct chlamydial serovariants that belong to 2 ...
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