Education
Ph.D., Rutgers University, U.S.A, 2005
Current position
Professor, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, China, 2009
Publications (since2014)
-
Huang, C., Zhang, Z., Chen, L., Lee, H., Ayrapetov, M., Zhao, T., Hao, Y., Gao, J., Yang, C., Mehta, G., Zhuang, Z., Zhang, X., Hu, G., Chin, E. Distinct Roles of Acetylation within the N- and C-terminal Domains of Src in STAT3-mediated Tumorigenesis Regulation. Cancer Res, in press.
-
Zhuang, X., Zhang, H., Li, X., Li, X., Cong, M., Peng, F., Yu, J., Zhang, X., Yang, Q. and Hu, G. (2017). Differential effects on lung and bone metastasis of breast cancer by Wnt signalling inhibitor DKK1. Nat Cell Biol 19(10): 1274-1285.
-
Huang, H., Zhang, W., Pan, Y., Gao, Y., Deng, L., Li, F., Li, F., Ma, X., Hou, S., Xu, J., Li, P., Li, X., Hu, G., Li, C., Chen, H., Zhang, L. and Ji, H. (2017). YAP Suppresses Lung Squamous Cell Carcinoma Progression via Deregulation of the DNp63-GPX2 Axis and ROS Accumulation. Cancer Res 77(21): 5769-5781.
-
Hu, J., Li, G., Zhang, P., Zhuang, X. and Hu, G. (2017). A CD44v(+) subpopulation of breast cancer stem-like cells with enhanced lung metastasis capacity. Cell Death Dis 8(3): e2679.
-
Li, N., Xue, W., Yuan, H., Dong, B., Ding, Y., Liu, Y., Jiang, M., Kan, S., Sun, T., Ren, J., Pan, Q., Li, X., Zhang, P., Hu, G., Wang, Y., Wang, X., Li, Q. and Qin, J. (2017). AKT-mediated stabilization of histone methyltransferase WHSC1 promotes prostate cancer metastasis. J Clin Invest 127(4): 1284-1302.
-
Panayotopoulou, E. G., Muller, A. K., Borries, M., Busch, H., Hu, G. and Lev, S. (2017). Targeting of apoptotic pathways by SMAC or BH3 mimetics distinctly sensitizes paclitaxel-resistant triple negative breast cancer cells. Oncotarget 8(28): 45088-45104.
-
Li, G., Li, M., Hu, J., Lei, R., Xiong, H., Ji, H., Yin, H., Wei, Q. and Hu, G. (2017). The microRNA-182-PDK4 axis regulates lung tumorigenesis by modulating pyruvate dehydrogenase and lipogenesis. Oncogene 36(7): 989-998.
-
Yu, P. F., Huang, Y., Xu, C. L., Lin, L. Y., Han, Y. Y., Sun, W. H., Hu, G. H., Rabson, A. B., Wang, Y. and Shi, Y. F. (2017). Downregulation of CXCL12 in mesenchymal stromal cells by TGFbeta promotes breast cancer metastasis. Oncogene 36(6): 840-849.
-
Yu, J., Lei, R., Zhuang, X., Li, X., Li, G., Lev, S., Segura, M.F., Zhang, X., Hu, G. (2016). MicroRNA-182 targets SMAD7 to potentiate TGFβ-induced epithelial-mesenchymal transition and metastasis of cancer cells. Nat Commun 7:13884.
-
Chen, X., Cao, X., Sun, X., Lei, R., Chen, P., Zhao, Y., Jiang, Y., Yin, J., Chen, R., Ye, D., Wang, Q., Liu, Z., Liu, S., Cheng, C., Mao, J., Hou, Y., Wang, M., Siebenlist, U., Eugene Chin, Y., Wang, Y., Cao, L., Hu, G. and Zhang, X. (2016). Bcl-3 regulates TGFbeta signaling by stabilizing Smad3 during breast cancer pulmonary metastasis. Cell Death Dis 7(12): e2508.
-
Liang, Y., Hu, J., Li, J., Liu, Y., Yu, J., Zhuang, X., Mu, L., Kong, X., Hong, D., Yang, Q. and Hu, G. (2015). Epigenetic Activation of TWIST1 by MTDH Promotes Cancer Stem-like Cell Traits in Breast Cancer. Cancer Res 75(17): 3672-3680.
-
Chen, F., Zhuang, X., Lin, L., Yu, P., Wang, Y., Shi, Y., Hu, G. and Sun, Y. (2015). New horizons in tumor microenvironment biology: challenges and opportunities. BMC Med 13: 45.
-
Zhou, Y., Wu, K., Jiang, J., Huang, J., Zhang, P., Zhu, Y., Hu, G., Lang, J., Shi, Y., Hu, L., Huang, T. and Kong, X. (2015). Integrative analysis reveals enhanced regulatory effects of human long intergenic non-coding RNAs in lung adenocarcinoma. J Genet Genomics 42(8): 423-436.
-
Wei, Q., Lei, R. and Hu, G. (2015). Roles of miR-182 in sensory organ development and cancer. Thorac Cancer 6(1): 2-9.
-
Li, X., Chen, X., Hu, G., Liu, Y., Zhang, Z., Wang, P., Zhou, Y., Yi, X., Zhang, J., Zhu, Y., Wei, Z., Yuan, F., Zhao, G., Zhu, J., Hu, L., Kong, X. (2014). Combined analysis with copy number variation identifies risk loci in lung cancer. Biomed Res Int 2014:469103.
-
Wan, L., Hu, G., Wei, Y., Yuan, M., Bronson, R. T., Yang, Q., Siddiqui, J., Pienta, K. J. and Kang, Y. (2014). Genetic ablation of metadherin inhibits autochthonous prostate cancer progression and metastasis. Cancer Res 74(18): 5336-5347.
-
Lin, B., Wang, Y., Wang, Z., Tan, H., Kong, X., Shu, Y., Zhang, Y., Huang, Y., Zhu, Y., Xu, H., Wang, Z., Wang, P., Ning, G., Kong, X., Hu, G. and Hu, L. (2014). Uncovering the rare variants of DLC1 isoform 1 and their functional effects in a Chinese sporadic congenital heart disease cohort. PLoS One 9(2): e90215.
-
Wang, Y., Lei, R., Zhuang, X., Zhang, N., Pan, H., Li, G., Hu, J., Pan, X., Tao, Q., Fu, D., Xiao, J., Chin, Y. E., Kang, Y., Yang, Q. and Hu, G. (2014). DLC1-dependent parathyroid hormone-like hormone inhibition suppresses breast cancer bone metastasis. J Clin Invest 124(4): 1646-1659.
-
Zhang, N., Wang, X., Huo, Q., Sun, M., Cai, C., Liu, Z., Hu, G. and Yang, Q. (2014). MicroRNA-30a suppresses breast tumor growth and metastasis by targeting metadherin. Oncogene 33(24): 3119-3128.
-
Lei, R., Tang, J., Zhuang, X., Deng, R., Li, G., Yu, J., Liang, Y., Xiao, J., Wang, H. Y., Yang, Q. and Hu, G. (2014). Suppression of MIM by microRNA-182 activates RhoA and promotes breast cancer metastasis. Oncogene 33(10): 1287-1296.